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What cxercise, vitamins, or food needed for diabetes/cardio risk individual?
2005-02-06 11:13:23
Hi,
Just wanted to get some advice from experts on how to improve my body health. I have a family history of diabetes and heart disease (two grandparents died fro these diseases). I know for a fact that I have genetically inherited some potential for both from these symptoms: 1) Poor gyclose metabolism - when I have a large meal, I will feel a mild burn in my kidneys/liver. I usually end up only burning 20-30% of a large meal, the rest goes straight to fat. Chromium picolinate and garcinia cambogia supplementation has helped a lot. A few years back, I did a daily routine of jogging 2 miles and taking chronimum+garcinia and lost 10 pounds. I recently did the same routine after having gained weight and was able to lose 10 pounds again. Unfortunately I gain weight when not using the chromium/garcinia on a regular basis. 2) Jogging capacity - I am unable to jog more than 2-3 miles at a time - I am muscularly in perfect shape, but after 2-3 miles, I get a severe cramp in my kidney/liver area, and inevitably have to stop. Is this related to sugar metabolism? 3) Body shape - after 10 years of working around, I am hard as a rock literally everywhere, except for my stomach (which is a very awkward body shape). Even below the waist, my thighs and butt are very toned. But starting below my rib cage to above my waist, I still pack 10-15 pounds of fat that appears nearly impossible to remove. Is there any way I can remove this? 4) Cholesterol - my total is well in a healthy range, however, my LDL (good cholesterol) is very very low - I have been trying to keep my cardio exercise up to increase it, but I wonder if there are other systemic reasons for why I would have a very low LDL. Based on these symptions, do you have any suggestions for creating improvement? In the short term, I want to remove the 10-15 pounds of fat so I don't look strange. In the long term, I want to take precautions through diet, exercise, and vitamin/mineral supplementation to ensure I don't have any substantial problems with diabetes or heart disease in the long run. All advice is greatly appreciated.
2005-02-06 16:22:56
analystresearch2002@yahoo.com wrote in message <1107717203.122628.226430@g14g2000cwa.googlegroups.com>... >Hi, > > Just wanted to get some advice from experts on how to improve my body >health. > > I have a family history of diabetes and heart disease (two >grandparents died fro these diseases). I know for a fact that I have >genetically inherited some potential for both from these symptoms: > >1) Poor gyclose metabolism - when I have a large meal, I will feel a >mild burn in my kidneys/liver. I usually end up only burning 20-30% of >a large meal, the rest goes straight to fat. Chromium picolinate and >garcinia cambogia supplementation has helped a lot. A few years back, >I did a daily routine of jogging 2 miles and taking chronimum+garcinia >and lost 10 pounds. I recently did the same routine after having >gained weight and was able to lose 10 pounds again. Unfortunately I >gain weight when not using the chromium/garcinia on a regular basis. > >2) Jogging capacity - I am unable to jog more than 2-3 miles at a time >- I am muscularly in perfect shape, but after 2-3 miles, I get a severe >cramp in my kidney/liver area, and inevitably have to stop. Is this >related to sugar metabolism? > >3) Body shape - after 10 years of working around, I am hard as a rock >literally everywhere, except for my stomach (which is a very awkward >body shape). Even below the waist, my thighs and butt are very toned. >But starting below my rib cage to above my waist, I still pack 10-15 >pounds of fat that appears nearly impossible to remove. Is there any >way I can remove this? > >4) Cholesterol - my total is well in a healthy range, however, my LDL >(good cholesterol) is very very low - I have been trying to keep my >cardio exercise up to increase it, but I wonder if there are other >systemic reasons for why I would have a very low LDL. > >Based on these symptions, do you have any suggestions for creating >improvement? In the short term, I want to remove the 10-15 pounds of >fat so I don't look strange. In the long term, I want to take >precautions through diet, exercise, and vitamin/mineral supplementation >to ensure I don't have any substantial problems with diabetes or heart >disease in the long run. > >All advice is greatly appreciated. > A few remarks: 1. Applause, applause for your efforts. Too many of us were ambushed by our genes in this area. 2. I suspect that your abdominal fat is genetic and probably a big part of the reason T2 diabetes runs in your family. Low carb helps. 3. I gather that you have low HDL (not LDL). AFAIK, that's another genetic symptom of a family with a high incidence of T2 diabetes. The only OTC techniques for improving HDL I know of are: a. Lots of exercise b. Pantethine (450 to 900 mg/day) c. Cinnamon (http://tinyurl.com/5usgr) d. Red wine 4. You didn't mention your triglycerides. Did you know that a triglycerides/HDL ratio above 3 (U.S. measurement, mg/dL) is dangerous and a sign of high Insulin Resistance? Some techniques in this area: a. Fish oil, 3000 mg/day b. Time-release niacin, 1000 mg/day c. Handful of walnuts each day (or some other nuts which I can't remember) d. Ground Flax seed daily Regards Old Al
2005-02-06 13:54:26
What medications are you taking? Any cholesterol lowering med, perhaps?
Such as cholestyramine (Questran) or a statin: lipitor, zocor, crestor... Zee analystresearch2002@yahoo.com wrote: > Hi, > > Just wanted to get some advice from experts on how to improve my > health. > > I have a family history of diabetes and heart disease (two > grandparents died fro these diseases). I know for a fact that I have > genetically inherited some potential for both from these symptoms: > > 1) Poor gyclose metabolism - when I have a large meal, I will feel a > mild burn in my kidneys/liver. I usually end up only burning 20-30% > a large meal, the rest goes straight to fat. Chromium picolinate and > garcinia cambogia supplementation has helped a lot. A few years > I did a daily routine of jogging 2 miles and taking > and lost 10 pounds. I recently did the same routine after having > gained weight and was able to lose 10 pounds again. Unfortunately I > gain weight when not using the chromium/garcinia on a regular basis. > > 2) Jogging capacity - I am unable to jog more than 2-3 miles at a > - I am muscularly in perfect shape, but after 2-3 miles, I get a > cramp in my kidney/liver area, and inevitably have to stop. Is this > related to sugar metabolism? > > 3) Body shape - after 10 years of working around, I am hard as a rock > literally everywhere, except for my stomach (which is a very awkward > body shape). Even below the waist, my thighs and butt are very > But starting below my rib cage to above my waist, I still pack 10-15 > pounds of fat that appears nearly impossible to remove. Is there any > way I can remove this? > > 4) Cholesterol - my total is well in a healthy range, however, my LDL > (good cholesterol) is very very low - I have been trying to keep my > cardio exercise up to increase it, but I wonder if there are other > systemic reasons for why I would have a very low LDL. > > Based on these symptions, do you have any suggestions for creating > improvement? In the short term, I want to remove the 10-15 pounds of > fat so I don't look strange. In the long term, I want to take > precautions through diet, exercise, and vitamin/mineral > to ensure I don't have any substantial problems with diabetes or > disease in the long run. > > All advice is greatly appreciated.
2005-02-07 05:32:26
news:1107717203.122628.226430@g14g2000cwa.googlegroups.com... > Hi, > > Just wanted to get some advice from experts on how to improve my body > health. > > I have a family history of diabetes and heart disease (two > grandparents died fro these diseases). I know for a fact that I have > genetically inherited some potential for both from these symptoms: > > 1) Poor gyclose metabolism - when I have a large meal, I will feel a > mild burn in my kidneys/liver. I usually end up only burning 20-30% of > a large meal, the rest goes straight to fat. Chromium picolinate and > garcinia cambogia supplementation has helped a lot. A few years back, > I did a daily routine of jogging 2 miles and taking chronimum+garcinia > and lost 10 pounds. I recently did the same routine after having > gained weight and was able to lose 10 pounds again. Unfortunately I > gain weight when not using the chromium/garcinia on a regular basis. > > 2) Jogging capacity - I am unable to jog more than 2-3 miles at a time > - I am muscularly in perfect shape, but after 2-3 miles, I get a severe > cramp in my kidney/liver area, and inevitably have to stop. Is this > related to sugar metabolism? > > 3) Body shape - after 10 years of working around, I am hard as a rock > literally everywhere, except for my stomach (which is a very awkward > body shape). Even below the waist, my thighs and butt are very toned. > But starting below my rib cage to above my waist, I still pack 10-15 > pounds of fat that appears nearly impossible to remove. Is there any > way I can remove this? > > 4) Cholesterol - my total is well in a healthy range, however, my LDL > (good cholesterol) is very very low - I have been trying to keep my > cardio exercise up to increase it, but I wonder if there are other > systemic reasons for why I would have a very low LDL. > > Based on these symptions, do you have any suggestions for creating > improvement? In the short term, I want to remove the 10-15 pounds of > fat so I don't look strange. In the long term, I want to take > precautions through diet, exercise, and vitamin/mineral supplementation > to ensure I don't have any substantial problems with diabetes or heart > disease in the long run. > > All advice is greatly appreciated. > The best way to lose weight is to eat less. Also you should have your blood sugar tested if you are worried about diabetes. The current recommendation is to try to catch this early and treat it before it starts causing symptoms. If it is low, you should still have it checked periodically - every year or so. Bill
2005-02-07 07:27:22
In addition to chromium, try vanadium, niacin, biotin, magnesium
B1, B6. The other B-vitamins would probably help as well. -- Cheers, Michael C Price ---------------------------------------- http://mcp.longevity-report.com http://www.hedweb.com/manworld.htm news:1107717203.122628.226430@g14g2000cwa.googlegroups.com... > Hi, > > Just wanted to get some advice from experts on how to improve my body > health. > > I have a family history of diabetes and heart disease (two > grandparents died fro these diseases). I know for a fact that I have > genetically inherited some potential for both from these symptoms: > > 1) Poor gyclose metabolism - when I have a large meal, I will feel a > mild burn in my kidneys/liver. I usually end up only burning 20-30% of > a large meal, the rest goes straight to fat. Chromium picolinate and > garcinia cambogia supplementation has helped a lot. A few years back, > I did a daily routine of jogging 2 miles and taking chronimum+garcinia > and lost 10 pounds. I recently did the same routine after having > gained weight and was able to lose 10 pounds again. Unfortunately I > gain weight when not using the chromium/garcinia on a regular basis. > > 2) Jogging capacity - I am unable to jog more than 2-3 miles at a time > - I am muscularly in perfect shape, but after 2-3 miles, I get a severe > cramp in my kidney/liver area, and inevitably have to stop. Is this > related to sugar metabolism? > > 3) Body shape - after 10 years of working around, I am hard as a rock > literally everywhere, except for my stomach (which is a very awkward > body shape). Even below the waist, my thighs and butt are very toned. > But starting below my rib cage to above my waist, I still pack 10-15 > pounds of fat that appears nearly impossible to remove. Is there any > way I can remove this? > > 4) Cholesterol - my total is well in a healthy range, however, my LDL > (good cholesterol) is very very low - I have been trying to keep my > cardio exercise up to increase it, but I wonder if there are other > systemic reasons for why I would have a very low LDL. > > Based on these symptions, do you have any suggestions for creating > improvement? In the short term, I want to remove the 10-15 pounds of > fat so I don't look strange. In the long term, I want to take > precautions through diet, exercise, and vitamin/mineral supplementation > to ensure I don't have any substantial problems with diabetes or heart > disease in the long run. > > All advice is greatly appreciated. >
2005-02-07 08:26:08
"Michael C Price" news:uLENd.385$Zy6.203@newsfe3-gui.ntli.net... > In addition to chromium, try vanadium, niacin, biotin, magnesium > B1, B6. The other B-vitamins would probably help as well. He may as well eat a bumper as go this route, it will help about as much and probably be cheaper. There are a lot of vitamin salesfolks in the world who will help you spend your money. Talk with your local doctor or dietician about changes in diet, and get a glucose tolerance test if you think you might have diabetes. In particular, untreated Type 2 diabetes can cause you to *gaini* weight.
2005-02-07 14:31:17
Nico Kadel-Garcia writes of my suggestion:
>> In addition to chromium, try vanadium, niacin, biotin, magnesium >> B1, B6. The other B-vitamins would probably help as well. > > He may as well eat a bumper as go this route, it will help about as > much and probably be cheaper. Cheaper, perhaps, but not as beneficial. > There are a lot of vitamin salesfolks in the world who will help you > spend your money. Perhaps there are, but I'm not in sales. Just a happy consumer. > Talk with your local doctor or dietician about > changes in diet, and get a glucose tolerance test if you think you might > have diabetes. In particular, untreated Type 2 diabetes can cause you > to *gaini* weight. Nico, there's plenty of evidence to support the items I listed. The fact that people like you and others are so quick to denounce anything outside your limited knowledge is a scandal -- but very predictable. Check out the numbered and annotated references in the text below for a more scientific and informed opinion. *********************************************** Glycation is the non-enzymic binding of glucose molecules to other molecules in general. This binding is uncontrolled and destructive, causing the faster aging exhibited by diabetics, and, since as we age we all tend to become pre-diabetic55, 83i-j (with reduced glucose tolerance, rising insulin and increased insulin-resistance and glucose levels), it is implicated in normal aging83. Animals fed chromium had lower fasting glucose and insulin levels and improved glucose tolerance. A range of studies on pigs, dogs and rodents suggest that glucose processing is optimised when the chromium intake in micrograms (ug) is above 1/5 of the number of calories consumed5d. In humans, chromium benefits both the healthy non-diabetics55 and diabetics, types I10d & II10, by improving HDL/LDL profiles, lowering insulin levels, fasting glucose levels and improving glucose tolerance. Both vitamins B3 (niacin)55a, B7 (biotin)55d and the mineral zinc137 synergise with chromium to improve insulin-resistance. Part of the reason why chromium deficiency is so common is that plants do not require chromium; plants can thrive in chromium poor soils, leading to chromium poor diets. Chromium optimises insulin function, which, in turn, lowers fasting glucose levels, improves glucose tolerance and reduces glycation. Chromium's anti-glycation, glucose-regulatory action is mediated entirely via the protein insulin (a hormone); chromium, therefore, is a proteonomic cofactor, but not an enzymic cofactor, with a single target protein, unlike the enzymic cofactors (which are proteonomic cofactors, since all enzymes are proteins), which operate via multiple enzymes. Therefore we have to be cautious in extrapolating the chromium rodent lifespan extension of 27% to humans; the control rats tested showed evidence of pre-diabetic, sub-clinical insulin resistance - their glycated haemoglobin levels increased almost 4-fold more as they aged5a, 5c (as a proportion of their lifespan) than in non-diabetic humans83i; the anti-aging effect on non-diabetic humans will probably be only a quarter as much, about 7%. Independently of any synergy with chromium, vitamins B1 (thiamine)88c-e, B3 (niacin)85, B6 (pyridoxine)88a-e, and B7 (biotin)93 along with minerals magnesium128, zinc91, in doses greater than the RDA, improve insulin-resistance and lower glycation levels. Calorie restriction (see later) also lowers glycation and extends lifespan, but whether it will synergise with the above micronutrients is unknown. Summary: chromium5, 10, 55, magnesium128 and zinc91, 137, along with vitamins B1 (thiamine)88c-e, B3 (niacin)55a, 85, B6 (pyridoxine)88a-e and B7 (biotin)55d, 93, are effective in preventing or ameliorating diabetes and, even in non-diabetics, reducing glycation levels, insulin-resistance and slowing aging. [5a] Composition and Biological Activity of Chromium-Pyridine Carboxylate Complexes. GW Evans and DJ Pouchnik, Journal of Inorganic Biochemistry 49, pg 177-187 (1993). PMID: 8433089 Describes the action of dietary chromium picolinate (relative to chromium chloride and chromium nicotinate) in reducing glycation & plasma glucose levels in rats as they aged. [5b] Longevity effect of chromium picolinate--'rejuvenation' of hypothalamic function? McCarty MF in Med Hypotheses 1994 Oct;43(4):253-65 PMID: 7838011 "The first rodent longevity study with the insulin-sensitizing nutrient chromium picolinate has reported a dramatic increase in both median and maximal lifespan.." Gives additional information about the Evans-Meyer-Pouchnik chromium picolinate experiment on rats: Cohort maximum lifespan (last survivor) was 48 months, extending the previous species maximum by 15% to give a total maximum lifespan increase of 26%. [5c] Chromium picolinate increases longevity. Evans GW, Meyer LK in AGE (the Journal of the American Aging Association) Oct 1992; 15(4), 134. [5d] Chromium Picolinate. Gary W Evans, (1996) ISBN 0895299119. Gives additional information about the Evans-Meyer-Pouchnik chromium picolinate experiment on rats: Mean lifespan extension of 27% However, the strain of rats used may have been pre-diabetic. [5e] The Longevity Factor: Chromium Picolinate. RA Passwater, (1993), ISBN 0879836199. [10a] Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, Feng J in Diabetes 1997 Nov;46(11):1786-91 PMID: 9356027 [10b] Nutritional factors influencing the glucose/insulin system: chromium. Anderson RA in J Am Coll Nutr 1997 Oct;16(5):404-10 PMID: 9322187 [10c] Beneficial effects of chromium in people with type 2 diabetes, and urinary chromium response to glucose load as a possible indicator of status. Bahijri SM, Mufti AM in Biol Trace Elem Res 2002 Feb;85(2):97-109 PMID: 11899964 [10d] [Chromium in the treatment of clinical diabetes mellitus] Ravina A, Slezack L in Harefuah 1993 Sep;125(5-6):142-5, 191 PMID: 8225092 "We gave 243 diabetic patients Cr (200 mcg/d) to study its effect on blood glucose balance. 105 were Type 1 (IDDM) and 138 Type 2 (NIDDM). Cr reduced insulin, sulfonylurea or metformin requirements in 115 patients. The success rate was greater in those with NIDDM (57.2%) than in those with IDDM (33.6%). More women, of either type, reacted than men (62.5 vs 50% in NIDDM and 37.6 vs 28.6% in IDDM). A placebo was ineffective." [55a] Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Urberg M, Zemel MB in Metabolism 1987 Sep;36(9):896-9 PMID: 3626867 "Sixteen healthy elderly volunteers were divided into three groups and given either 200 micrograms Cr, 100 mg nicotinic acid, or 200 micrograms Cr + 100 mg nicotinic acid daily for 28 days and evaluated on days 0 and 28. Fasting glucose and glucose tolerance were unaffected by either chromium or nicotinic acid alone. In contrast, the combined chromium-nicotinic acid supplement caused a 15% decrease in a glucose area integrated total (p less than .025) and a 7% decrease in fasting glucose." [55b] Effect of chromium supplementation on glucose tolerance and lipid profile. Bahijri SM in Saudi Med J 2000 Jan;21(1):45-50 PMID: 11533750 "Improved glucose control, and lipid profile following chromium supplement suggests the presence of low chromium status in the studied population. However, serum chromium could not be recommended for use as an indicator of chromium status as subjects with widely varying levels responded favorably to the chromium supplement." [55c] The safety and efficacy of high-dose chromium. Lamson DS, Plaza SM in Altern Med Rev 2002 Jun;7(3):218-35 PMID: 12126463 "The beneficial effects of chromium on serum glucose and lipids and insulin resistance occur even in the healthy." [55d] High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes. McCarty MF in Med Hypotheses 1999 May;52(5):401-6 PMID: 10416947 [55e] Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Offenbacher EG, Pi-Sunyer FX in Diabetes 1980 Nov;29(11):919-25 PMID: 7000589 "Thus, chromium-rich brewers' yeast improved glucose tolerance and total lipids in elderly subjects, while chromium-poor torula yeast did not. An improvement in insulin sensitivity also occurred with brewers' yeast supplementation. This supports the thesis that elderly people may have a low level of chromium and that an effective source for chromium repletion, such as brewers' yeast, may improve their carbohydrate tolerance and total lipids." [55f] Effects of chromium supplementation on fasting insulin levels and lipid parameters in healthy, non-obese young subjects. Wilson BE, Gondy A in Diabetes Res Clin Pract 1995 Jun;28(3):179-84 PMID: 8529496 "However, those individuals [6/15] within the chromium group with initial fasting IRI levels greater than 35 pmol/l had a significant decrease in IRI level after supplementation (P < 0.03) despite no significant changes in serum lipids. These subjects may benefit from chromium supplementation by improving insulin sensitivity and cardiovascular risk over time." [85] Safety of high-dose nicotinamide: a review. Knip M, Douek IF, Moore WP, Gillmor HA, McLean AE, Bingley PJ, Gale EA in Diabetologia 2000 Nov;43(11):1337-45 PMID: 11126400 Discusses the potential of 3g/d vitamin B3 in preventing the onset of Type I (insulin-dependent) diabetes. [88a] Amadorins: novel post-Amadori inhibitors of advanced glycation reactions. Khalifah RG, Baynes JW, Hudson BG in Biochem Biophys Res Commun 1999 Apr 13;257(2):251-8 PMID: 10198198 "This in turn led to a unique and rapid post-Amadori screening assay for putative "Amadorins," which we define here as inhibitors of the conversion of Amadori intermediates to AGEs in the absence of excess free or reversibly bound (Schiff base) sugar. Our screening assay then led to the identification of pyridoxamine (Pyridorin) as the first member of this class of Amadorin compounds. Rather unexpectedly, the assay also led to the clear demonstration that the well-known AGE inhibitor aminoguanidine, currently in Phase 3 clinical trials for treatment of diabetic nephropathy, has negligible Amadorin activity. In view of the importance of Amadori compounds as intermediates in AGE formation in vivo, the therapeutic potential of Pyridorin is currently being investigated and is now showing highly promising results in different animal models." [88b] Glycoxidation and lipoxidation in atherogenesis. Baynes JW, Thorpe SR in Free Radic Biol Med 2000 Jun 15;28(12):1708-16 PMID: 10946212 "advanced lipoxidation end-products (ALEs). The ALEs and their precursors affect the structure and function of the vascular wall, setting the stage for atherogenesis. The increased risk for atherosclerosis in diabetes may result from additional carbonyl production from carbohydrates and additional chemical modification of proteins by advanced glycation end-products (AGEs). Failure to maintain homeostasis and the increase in oxidizable substrate (lipid) alone, rather than oxidative stress, is the likely source of the increase in reactive carbonyl precursors and the resultant ALEs and AGEs in atherosclerosis. Nucleophilic AGE-inhibitors, such as aminoguanidine and pyridoxamine, which trap reactive carbonyls and inhibit the formation of AGEs in diabetes, also trap bioactive lipids and precursors of ALEs in atherosclerosis. These drugs should be effective in retarding the development of atherosclerosis, even in nondiabetic patients." [88c] [Diabetes and vitamin levels] Tamai H in Nippon Rinsho 1999 Oct;57(10):2362-5 PMID: 10540887 "Administration of vitamins to diabetic patients reduces insulin requirement and attracts much attention for improvement of vascular complications. Vitamins play as not only nutritional supplements for deficiency, but pharmacological agents for treatment." [88d] In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways. Booth AA, Khalifah RG, Todd P, Hudson BG in J Biol Chem 1997 Feb 28;272(9):5430-7 PMID: 9038143 "Of several derivatives of vitamins B1 and B6 recently studied for possible AGE inhibition in the presence of glucose (Booth, A. A., Khalifah, R. G., and Hudson, B. G. (1996) Biochem. Biophys. Res. Commun. 220, 113-119), pyridoxamine and, to a lesser extent, thiamine pyrophosphate proved to be novel and effective post-Amadori inhibitors that decrease the final levels of AGEs formed." [88e] Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine. Booth AA, Khalifah RG, Hudson BG in Biochem Biophys Res Commun 1996 Mar 7;220(1):113-9 PMID: 8602828 "Among the inhibitors, pyridoxamine and thiamine pyrophosphate potently inhibited AGE formation and were more effective than aminoguanidine, suggesting that these two compounds may have novel therapeutic potential in preventing vascular complications of diabetes." [93a] Urinary biotin analogs increase in humans during chronic supplementation: the analogs are biotin metabolites. Mock DM, Heird GM in Am J Physiol 1997 Jan;272(1 Pt 1):E83-5 PMID: 9038855 [93b] Biotin supplementation improves glucose and insulin tolerances in genetically diabetic KK mice. Reddi A, DeAngelis B, Frank O, Lasker N, Baker H Life Sci 1988;42(13):1323-30 PMID: 3280936 [93c] Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients. Koutsikos D, Fourtounas C, Kapetanaki A, Agroyannis B, Tzanatos H, Rammos G, Kopelias I, Bosiolis B, Bovoleti O, Darema M, Sallum G in Ren Fail 1996 Jan;18(1):131-7 PMID: 8820510 [93d] [Enhancement of glucose-induced insulin secretion and modification of glucose metabolism by biotin] Furukawa Y in Nippon Rinsho 1999 Oct;57(10):2261-9 PMID: 10540872 [93e] Biotin administration improves the impaired glucose tolerance of streptozotocin-induced diabetic Wistar rats. Zhang H, Osada K, Sone H, Furukawa Y in J Nutr Sci Vitaminol (Tokyo) 1997 Jun;43(3):271-80 PMID: 9268917 [93f] A high biotin diet improves the impaired glucose tolerance of long-term spontaneously hyperglycemic rats with non-insulin-dependent diabetes mellitus. Zhang H, Osada K, Maebashi M, Ito M, Komai M, Furukawa Y in J Nutr Sci Vitaminol (Tokyo) 1996 Dec;42(6):517-26 PMID: 9089478 [128a] Magnesium supplementation reduces development of diabetes in a rat model of spontaneous NIDDM. Balon TW, Gu JL, Tokuyama Y, Jasman AP, Nadler JL in Am J Physiol 1995 Oct;269(4 Pt 1):E745-52 PMID: 7485490 "We examined the effects of a magnesium-supplemented (Mg-S) diet in the male obese Zucker diabetic fatty rat, a model of non-insulin-dependent diabetes mellitus (NIDDM). Obese rats were maintained on either a control (0.20% Mg) or magnesium-supplemented (Mg-S; 1% Mg) diet for 6 wk beginning at 6 wk of age. The rats maintained on the Mg-S diet had markedly lower fasting and fed-state blood glucose concentrations and an improved glucose disposal. By 12 wk of age, all of the eight animals on the control diet became diabetic, whereas diabetes developed in only one of eight animals on the Mg-S diet. Insulin and C-peptide concentrations, in addition to pancreatic GLUT-2 and insulin mRNA expression, were higher in the male obese Mg-S rats than in their control-fed counterparts. A subgroup of rats on the control diet with established diabetes was switched to a Mg-S diet for an additional 4 wk. The Mg-S diet did not reverse diabetes once already established. These data indicate that an increased dietary Mg intake in male obese rats prevents deterioration of glucose tolerance, thus delaying the development of spontaneous NIDDM." [128b] Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats. Matsuda M, Mandarino L, DeFronzo RA in Metabolism 1999 Jun;48(6):725-31 PMID: 10381146 "Based on these results, MgV is superior to either V alone or Mg alone in improving insulin sensitivity and glycogen synthesis in diabetic rats." [128c] The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Lima Mde L, Cruz T, Pousada JC, Rodrigues LE, Barbosa K, Cangucu V in Diabetes Care 1998 May;21(5):682-6 PMID: 9589224 "In the placebo and in the 20.7 mmol [0.5g] Mg groups, neither a change in plasma and intracellular levels nor an improvement in glycemic control were observed. Replacement with 41.4 mmol [1g] Mg tended to increase plasma, cellular, and urine Mg and caused a significant fall (4.1 +/- 0.8 to 3.8 +/- 0.7 mmol/l) in fructosamine (normal, 1.87-2.87 mmol/l). CONCLUSIONS: Mg depletion is common in poorly controlled patients with type 2 diabetes, especially in those with neuropathy or coronary disease. More prolonged use of Mg in doses that are higher than usual is needed to establish its routine or selective administration in patients with type 2 diabetes to improve control or prevent chronic complications." [128d] Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects. Paolisso G, Sgambato S, Pizza G, Passariello N, Varricchio M, D'Onofrio F in Diabetes Care 1989 Apr;12(4):265-9 PMID: 2651054 "In eight aged non-insulin-dependent diabetes mellitus (NIDDM) subjects, insulin response and action were studied before and after chronic magnesium supplementation (2 g/day) to diet. [.] In conclusion, our data suggest that NIDDM subjects may benefit from therapeutic chronic administration of magnesium salts." [128e] Daily magnesium supplements improve glucose handling in elderly subjects. Paolisso G, Sgambato S, Gambardella A, Pizza G, Tesauro P, Varricchio M, D'Onofrio F in Am J Clin Nutr 1992 Jun;55(6):1161-7 PMID: 1595589 "aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. [.] CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling." [128f] Magnesium Intake and Risk of Type 2 Diabetes in Men and Women. Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB in Diabetes Care. 2004 Jan;27(1):134-140. PMID: 14693979 "Our findings suggest a significant inverse association between magnesium intake and diabetes risk." [137] Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni A in J Am Coll Nutr 2001 Jun;20(3):212-8 PMID: 11444416 "CONCLUSIONS: These data suggest the potential beneficial antioxidant effects of the individual and combined supplementation of Zn and Cr in people with type 2 DM. These results are particularly important in light of the deleterious consequences of oxidative stress in people with diabetes." -- Cheers, Michael C Price ---------------------------------------- http://mcp.longevity-report.com http://www.hedweb.com/manworld.htm |
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